About

Project Facts

Project name: Innovative water-soluble phytomaterial inhibitors for Alzheimers and Parkinsons diseases prevention

Project acronym: PhytoAPP

Call: H2020-MSCA-RISE-2020

Type of action: MSCA-RISE

Number: 101007642

OUR IDEA

The PhytoAPP conceptual idea is a development of inhibitors of amyloid fibrils formation and hence Alzheimer’s and Parkinson’s disease prevention/treatment through advancement in innovative nanotech approach to overcome the phytochemicals’ limitations of low water-solubility, thus resolving issues with low bioavailability, low stability, high concentration requirements and increased toxicity. Developing reliable products and processes in the Lab scale as water-soluble nano-enabled Phytocomplexes synthesis and their in vitro and in vivo testing, work within the project is also aimed at the preparatory steps elaboration for scaling up production of the nanopharmaceutical products (such as Pilot scale Lines development/ upgrade/adjustment, certification/specification of the process/product requested for the nanopharmaceuticals production, product preparation for further large animal mode in vivo and clinical testing, etc.).

PROJECT STRUCTURE

WP1 Advanced Materials Reference Onset Elaboration

1.1. Design and Optimization of the synthetic pathways towards reliable and reproducible Lab Scale synthesis of the nano-enabled Phytochemical water-soluble materials
Task 1.2 Morphological and Structural Characterization/Validation of elaborated complexes
Task 1.3 Functional [Nano-Phyto] core structures elaboration

WP2 Comprehensive studies on inhibition of amyloid fibrils formation

Task 2.1 Extended studies on inhibition of amyloid fibrils formation
Task 2.2 Extended Bioactivity Testing: in vitro anti-viral, anti-oxidant; UV-protection of the PhytoAPP products Nanotoxicity assessment

WP3 Novel materials Preclinical studies

Task 3.1 Preclinical in vitro Assays
Task 3.2 Preclinical in vivo Studies

WP4 Innovative materials Scaling up and Fabrication

Task 4.1 Upgrade/develop material’s production facilities
Task 4.2 Fabrication of the elaborated nanopharmaceuticals

WP5 Novel PhytoAPP products specification, certification for medical application

Task 5.1 Documentation preparation
Task 5.2 Exploitation Plan

WP6 Management, Dissemination and Public Engagement of the project

Task 6.1 Project Management Plan
Task 6.2 Visual identity of the project
Task 6.3 Dissemination and Communication Plans
Task 6.4 Professional development via exchange of staff
Task 6.5 Dissemination of scientific results

DELIVERABLES

D2.1 PROTOCOL on in vitro Bioactivity Testing, NANOTOXICITY Assessment
D2.2 KINETICS of the Amyloid Fibril Formation in a presence of elaborated Phytomaterials
D2.3 Operation MECHANISM SIMULATION
D2.4 Protocol in vitro testing anti COVID 19
D3.1 PROTOCOL on d in vivo PRECLINICAL STUDY
D5.2 Novel PhytoAPP products CERTIFICATION for Medical Application
D5.3 Environmental RISK ASSESSMENT
D6.1 Data Management Plan
D6.2 Dissemination and Communication Plans
D6.3 1st Progress Report
D6.4 1st Workshop
D6.5 2nd Workshop
D6.6 Social event Introduction to the General Public
D6.7 Summer School
D6.8 2nd Progress Report
D6.9 3rd Workshop
D6.10Project Conference